The SUPREP box contains 2 brown bottles and a disposable 16oz cup for mixing. “Eggs that have just been laid by hens should be refrigerated immediately,” Amidor says. When it’s time for a liquid diet, change it up a little. * If you have an early morning procedure, you may have to wake up very early. Medications. Break up your prep drink. Yes, you should refrigerate a cake with cream cheese frosting. You should be prepared to be near the bathroom during this preparation. Having a clean colon allows your provider to see the inside of your colon more clearly during a colonoscopy. The second dose needs to be taken around. You will need to pick-up your prescription at your pharmacy. This can happen even if you have never had a seizure. Refrigerate the rest of the prep for the second dose. Was still able to do the colonoscopy, but it was a terrible experience. 5-ounces of an oral Everything from fresh fruits, leftovers, and breads can be extended by days by properly storing it in a refrigerator. Drink the whole container. Suck on ice or a lemon or lime wedge. To keep your pie as fresh as possible, be sure to wrap it loosely in plastic wrap or aluminum foil. adding flavor, tear open flavor packet and mix with solution. Add cool water to the 16oz line and mix. Suprep. Suprep is not recommended for use in children under the age of 18, and it is not recommended for use. The potential for uric acid elevation should be considered before administering SUPREP Bowel Prep Kit to patients with gout or other disorders of uric acid metabolism. Downed it in less than 5 minutes in 3-4 big slurps. Instead, you’ll take one the night before your exam, and the other the morning of your exam. Warnings. (212) 427-8761 Manhattan Gastroenterology (Union Square) 55 W 17th St Ste 102, New York 10011. m. Eggs stored unrefrigerated should not be washed until they are used. Laxatives. 13 grams sodium sulfate, 2. Went. But once you get beyond the taste it definitely does the trick and considering its basically just electrolytes (various salts) you wont have issues with that if you drink the required water. Keep insulin lispro in its original container protected from heat and light. The day of your colonoscopy. corn, including popcorn. Drink it cold and through a straw. 5. Step 2. Suprep is a combination bowel prep kit. In other words, it leaves the smallest amount of poop in your colon. This information is not intended as a substitute for professional judgment. S. It is important to drink the additional clear liquids as recommended in the Instructions for Use. Clenpiq: told it was so much better than Suprep, but the only difference to me was the volume. Severe stomach pain or bloating, bloody or black stools. And if your kitchen naturally runs at that temperature, you're in good shape. Suck on ice or a lemon or lime wedge. Refrigerate the solution and drink it cold. I never could drink the two, 16 oz. Discontinue all blood thinning drugs (prescription and non-prescription), including:. Add water to the fill line and. I used a straw and chased each intake with lemon lime Gatorade. Chilling the prep in the. Step 3: Drink all the liquid in the container. These changes can cause: • abnormal heartbeats that can cause death • seizures. This is a low volume prep (2 liters) and it's loaded with vitamin C it taste like a tart lemon aid and is safe in all patient types. Ask your doctor before changing your dose or medication schedule. Colonoscopy prep: Suprep [Fact sheet]. Additionally, eating a light meal prior to taking Suprep can also help to speed up the process. Suprep is a prescription medication used to cleanse the colon in preparation for a colonoscopy. TL;DR - if you need a colonoscopy, ask for the suprep split dose for the simultaneous best results and least miserable prep in my (considerable) experience. The time it takes to get to this point. ) to our armamentarium and are gaining experience with it. 19,326 satisfied customers. Whether they're. Using the flavored water can help cover up the taste from the laxative. The study concludes: "The bowel preps with the best bowel cleansing and tolerability were MiraLAX with Gatorade, MoviPrep, and SUPREP under real-world conditions. The best way to store unripe Avocados is in the refrigerator. Is Suprep a laxative? Yes,. (3) • SUPREP Bowel Prep Kit (for pediatric patients 12 years of age and older): Two bottles each containing 4. The time it takes to get to this point. Having the stems intact will protect the interior of your berries and prolong their shelf life. Was still able to do the colonoscopy, but it was a terrible experience. Suprep. Each dose consists of one bottle of. If not, leave it for 5 more minutes. You can slow ripening by storing tomatoes at around 50 degrees, in somewhere like a root cellar or a small wine fridge devoted to produce, McDermott says. ColPrep Kit; Suprep Bowel Prep Kit; Descriptions. • SUPREP Bowel Prep Kit (for adults): Two bottles each containing 6 ounces of an oral solution of 17. 5 grams sodium sulfate, 3. I’m sorry but it’s awful. 5-ounces of an oral the initial 16 ounces of the SUPREP for a total of 48 ounces MORNING OF PROCEDURE • Do not take any of your usual diabetic medications. Here’s the verdict: The liquid is clear. Applies to magnesium sulfate / potassium sulfate / sodium sulfate: oral solution. Do not take oral medications within one hour of starting CLENPIQ. If you feel nauseated, drink Suprep more slowly. How to take it: Two 12-ounce doses, each followed by a quart of water. m. Yes, in the U. You can store them at room temperature for up to 24-36 hours, depending on the humidity in your kitchen. In a container, donuts can last for up to 5 days in a fridge. 2. SUPREP Bowel Prep Kit is taken mixed with water as a split dose (2-day) regimen. Mild nausea, bloating or feeling of fullness. You may have small sips of Sprite or Ginger Ale along with the prep to help settle your. Refrigerator: The fridge is the most obvious methods to store cooked oatmeal. Step 3 – Mix Second Dose (Dose 2 Packet A and B) Pour one (1) 6 oz. Your chance of having fluid loss and changes in body salts with Sodium Sulfate, Potassium Sulfate and Magnesium Sulfate Oral Solution is higher if you: have heart problems; have. Take the first dose (1 bottle) of CLENPIQ in the afternoon or early evening before the colonoscopy (e. However, be aware that the longer you store cheese in the fridge, the more it will dry out and become hard. A prescription will be sent to your pharmacy ONE WEEK before your procedure. m. You MUST drink a total of 32 ounces of clear liquid over the next hour. Chilling it: Anecdotal evidence suggests that prep drinks taste worse when warm, so it may help to refrigerate the prep or drink it over ice. • SUPREP Bowel Prep Kit (for adults): Two bottles each containing 6 ounces of an oral solution of 17. I used a straw too. Pour one (1) 6-ounce bottle of SUPREP liquid into the mixing container. MoviPrep, Prepopik, Suprep: Drink the first dose, and then drink the specified amount of clear liquids, as detailed in the package instructions. SUTABKeep It Cool (But Not Cold) The most crucial factor for storing garlic is temperature. Fax: 1-510-595-8183. The Miralax can be mixed into Gatorade or another clear liquid to make the solution tastier. While one study found that allowing washed eggs to sweat won’t impact egg freshness, the USDA maintains that sweating can prompt bacteria growth and recommends that eggs shouldn’t be left unrefrigerated for more than 2 hours (1 hour if it’s hotter than. com. You can take these afterwards. Freshly picked potatoes should be “cured” in warmer temperatures and high humidity for a. It began to work within 30 minutes. Can you buy Suprep over-the-counter? No, Suprep is only available as a prescription from your provider to prepare you for a colon cleansing before a colonoscopy. Some may drink the entire 22-ounces all at once. Dose 1: One bottle (6 ounces) taken early in the evening before colonoscopy, 10 to 12 hours before the second dose. If you’re not eating them right away, it’s best to put them in the fridge until you’re ready to eat them. Up once or twice in the night, but overall a much nicer experience. SUPREP ® Fill line. • If you want to drink a chilled solution of SUPREP, mix the solution ahead of time and refrigerate it before drinking. e. The laxative can take effect within 1‐4 hours. adding flavor, tear open flavor packet and mix with solution. Put the airtight container into the refrigerator. Next was miralax & Gatorade. Veteran Member. 5-ounces of an oralTake 1st and refrigerate prior to drinking. Medically Reviewed. This preparation is supplied in powdered form, for oral. The taste, we we all know it sucks. ; please refer to product literature booklet which comes packaged inside every suprefactory sealed pouch/box. How Long Is Cooked Chicken Good For In the Fridge? According to the U. The worst part of the process was going without solid food for an entire 24-hours. The second half of your prep should be started 4-5 hours before the time of your colonoscopy. Consume the solution slowly in 10 to 20-minute intervals over the course of three hours. Drink the solution at a rate of 8 oz every 10 min starting at 5:00-6:00PM. Add cool drinking water to the 16 ounce line. Reviews and ratings for Suprep Bowel Prep Kit when used in the treatment of bowel preparation. One of the primary reasons why Suprep is not covered by insurance is its cost. − Drink ALL the liquid in the container. In. - Mix to dissolve. *Get plenty of rest the week and night before beginning prep. 13 grams potassium sulfate, and 1. A few flecks of stool will be OK. 5 hours before your procedure time: Start 2nd dose of SUPREP and complete steps 1-4 using the other 6-ounce bottle: Step 1: Pour ONE (1) 6-ounce bottle of SUPREP liquid into the mixing container. "There are four main enemies of cooking oil—time, heat, oxygen, and light," she explains. Using Suprep to Prepare for Colonoscopy. If you take them out of their packet, put them. Soft cheeses. 13 grams potassium sulfate, and 1. Refrigerate Them. Here are a few herbal tea options that can help make Suprep more tolerable: Ginger Tea: Ginger can help to settle the stomach and has a bit of a spicy kick that can help to mask the taste of Suprep. The Miralax can be mixed into Gatorade or another clear liquid to make the solution tastier. Suprep is a low-volume prep, and the tablets are the other alternative. (3) • SUPREP Bowel Prep Kit (for pediatric patients 12 years of age and older): Two bottles each containing 4. The first dose is usually taken the night before the colonoscopy and the second dose taken the morning of the procedure. Didn’t really taste it at all. SUPREP Bowel Prep Kit should be given to a pregnant woman only if clearly needed. So you drink one bottle at 5pm the night before, and then you MUST MUST drink 5 8oz glasses of water as soon as you can, to keep yourself hydrated. When you are ready to use, thaw at room temp in sealed containers. 3oz of MiraLAX and refrigerate (do not add ice) At 6pm, begin taking your prep solution. As with most foods, the quality gradually starts to decline over time, but even after two days in the refrigerator, a properly wrapped pie will. Tell your doctor about all your current medicines and any. PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride for oral solution, supplied as a powder, must be reconstituted with water before its use; it is not for direct ingestion [see Dosage and Administration (), Warnings and Precautions ()]. 5 to 6 pm on the Day Before the Exam. Suprep can cause severe dehydration, which can lead to a serious electrolyte imbalance, seizures, or kidney failure. Drink each glass quickly rather than drinking small amounts continuously. Stay near a toilet! You will have diarrhea, which can be quite sudden. On the evening before the colonoscopy, open 1 bottle of Suprep Bowel Prep Kit® and pour the contents into the mixing container provided. The second dose needs to be. Linzess (43 questions, 189 members) Suprep (22 questions, 50 members) Suprep Bowel Prep Kit (5 questions, 12 members) Bowel Preparation (28 questions, 42 members) Pre-Exposure Prophylaxis (19 questions, 9 members) Medical Disclaimer SUPREP Bowel Prep Kit (for pediatric patients 12 years of age and older): Two bottles each containing 4. Recommended Dosage and Administration for Adults. The osmotic laxative will be marketed by Braintree Laboratories, Inc. Download the CLENPIQ coupon and your patients may be eligible to pay as little as $40 if they have commercial insurance, or to take $40 off the cash price. THE AFTERNOON OR EVENING BEFORE THE COLONOSCOPY. Certain types of donuts do not have to be refrigerated if they are going to be eaten within two days. bottle of SUPREP into the disposable container. 5 grams sodium sulfate, 3. • SUPREP Bowel Prep Kit (for adults): Two bottles each containing 6 ounces of an oral solution of 17. , eggs need to be refrigerated. Empty one bottle into the mixing container and fill it with cold water up to a 16-ounce line. Make sure that your fridge is set to 4 °C (39 °F) when you store the sample. Nothing. Posted 6/11/2015 2:07 PM (GMT -8) I. Refrigerate the Suprep solution before drinking, it tastes better chilled. of water or the clear liquid of your choice overUse drink flavoring agents to mask the taste and smell of Suprep. Successfully save leftover cooked oatmeal using three distinct methods, refrigerating, freezing or dehydrating. 5-ounces of an oralThe Suprep Bowel Prep Kit, for example, requires drinking just two cups of liquid laxative — once in the evening before your procedure, and once the morning of. (3) • SUPREP Bowel Prep Kit (for pediatric patients 12 years of age and older): Two bottles each containing 4. 13 g/1. 6 grams magnesium sulfate. Some newer colonoscopy preparation alternatives. 13 grams potassium sulfate, and 1. The first dose is usually taken the night before the colonoscopy and the second dose taken the morning of the procedure. Suprep Split-Dose Colon Prep Instructions; Sigmoidoscopy Preparations. I drank it chilled from the refrigerator. 1,333 satisfied customers. Some find drinking it cold and through a straw helpful, and others mix it with a sports drink or powdered drinks mix. After shaking, put mixture into the refrigerator. Suprep can cause severe dehydration, which can lead to a serious electrolyte imbalance, seizures, or kidney failure. You have to drink the solution within 24 hours of mixing it. All. This medicine is a laxative. )Refrigerate the solution and drink it cold. Suprep is effective in cleansing the bowels in as little as two hours, but the duration of Suprep in your system can be affected by a number of factors. Individual portions can be separated and saved in the fridge for 3 to 5 days. Also, drink plenty of clear liquids and avoid anything with red. – Repeat all 4 steps again with another 6-ounce bottle of Suprep. Processed cheese will last for several months. Solution dose Pour 1 -6oz bottle of SUPREP into the disposable container. Step 2: Add cool drinking water to the 16-ounce line on the container and mix. 13 grams potassium sulfate, and 1. do not follow the instructions from the phArmAcy. Suprep split dose both sucks less and works better, in my considerable experience. • SUPREP Bowel Prep Kit (for adults): Two bottles each containing 6 ounces of an oral solution of 17. Refrigeration is not necessary but can be done if desired. Suck on a lemon or hard candy afterward. You can also refrigerate the drink and drink it quickly to lower the unpleasant sensations. I’ve found that this method really helps to make the taste more bearable. Important: Suprep Bowel Prep Kit is a drug containing multiple ingredients. 3. liquid or sipping through a straw makes it easier. Uric acid fluctuations in patients with gout may precipitate an acute flare. SUPREP Bowel Prep Kit and other osmotic bowel preparations can cause serious side effects, including: Serious loss of body fluid (dehydration) and changes in blood salts (electrolytes) in your blood. The solution will be clear and colorless. Pour ONE (1) 6 ounce bottle of Suprep into the supplied mixing cup; add cold drinking water or berry flavored water to the 16 ounce fill line on the mixing cup and stir. (NOTE: Dilute the solution concentrate as directed prior to use. In Conclusion. Some patients find Suprep more tolerable when chilled. The day before your colonoscopy. Learn how to use it. Medical staff typically recommend that 3 days before a colonoscopy, a person should avoid: nuts. 5 grams sodium sulfate, 3. Phone: 1-800-321-4576. Good luck and remember. Sodium Sulfate. • At 5:30 p. Take 4 tablets of bisacodyl (Dulcolax) around 3:00-4:00 PM. 5 g/3. A single dose of Suprep can cost around $100, and the standard bowel prep requires two doses, which means patients need to pay $200 on average. The sample will stay fresh for up to an extra day. "Grapefruit can be stored in warmer temps, up to 48 degrees. Warnings. Any remaining stool can hide lesions and can result in the need to repeat the procedure . 13 grams potassium sulfate, and 1. Each dose consists of one bottle of. , take the first dose SuPrep as follows: Pour ONE 6 ounce bottle of SuPrep liquid into the mixing container. Description and Brand Names. Do not add ice into the mixing container. hunter washington hudl; passive aggressive communication examples sentencesPeeled onions can be stored in the fridge for 10–14 days, while sliced or cut onions can be refrigerated for 7–10 days. 13 grams potassium sulfate, and 1. That will make it more palatable. To keep your pie as fresh as possible, be sure to wrap it loosely in plastic wrap or aluminum foil. * You can continue to drink clear liquids up until 4 hours before your scheduled time. MEDICATIONS: Please take heart medications or blood pressure medications, other than water pills, with a glass of water 4 hours before the scope or the night before. Place in refrigerator to cool. You can also keep pumpkin pie at room temperature for up to two hours, according to the FDA. (212) 427-8761 Manhattan Gastroenterology (Midtown) 56 W 45th St, Ste 802, New York 10036. 13th and I decided to use one packed of Crystal Light in mine. Drank as much as I could then chased with lemonade and sucked on a sugared lemon wedge. "Refrigerated everything. If you are having difficulty tolerating the Suprep you must consult with the surgery. It is important to drink the additional clear liquids as recommended in the Instructions for Use. Suck on a lemon just before and after sipping the Moviprep. Then drink (2) 16 ounces of a clear liquid of your choice. (This applies to real maple syrup as well as commercial pancake syrup. 7:00 p. People feel it is better tolerated cold. can i mix suprep with anything besides water. AT 5:00 PM: Drink the first dose of your prep; drink 8 ounces every 15 minutes until the entire container is consumed. le bossu de notre dame paroles infernal. Nucala (mepolizumab) is only stable at room temperature (max 86°F/30°C) for. Drink the solution. Prepare the figs by washing them and removing the stems. Suprep can be unpleasant to taste and smell, making it difficult to consume. The preps used for split dose preps are Plenvu, Osmoprep Tablets, Clenpiq, and Suprep. The taste is like (insert your personal aweful tasting thing here). Some people also prefer to drink MoviPrep with a straw. Each 4 liter bottle contains polyethylene glycol-3350 240 g, sodium chloride 5. The laxative will cause you to have very loose, watery stools. For many of us, it's a challenge to find a cool spot like this in. 5 grams, potassium sulfate 3. 1. Step 3 – Mix Second Dose (Dose 2 Packet A and B) Pour one (1) 6 oz. 4. It. - Add cool drinking water to the 16 ounce line on the container. You will need to pick-up your prescription at your pharmacy. 4. 1615 reviews submitted with a 7. are bombas socks ethically made; brian perri surgeon net worth; black crow navis 2018Keep those little, frilly green stems on your fresh strawberries when storing in the refrigerator. Drinking with a straw is helpful. • If taking plavix, eent, Aggrenox, coumadin, eliquis, pradaxa or any blood thinning medication, please inform our nurse at the time of call. I mixed it with ice cold water, and used the straw on the back of my tongue. 3. Smucker’s recommends thawing Uncrustables for 30–60 minutes at room temperature and eating them within 6–8 hours for the best flavor. 5 grams sodium sulfate, 3. You need to follow the SUPREP instructions and be prepared to drink a lot of liquid. (3) • SUPREP Bowel Prep Kit (for pediatric patients 12 years of age and older): Two bottles each containing 4. If you use the suprep, mix it with crystal light lemonade, it makes the taste and smell way better! Thanks for the input!Step 1- Pour ONE (1) 6-ounce bottle of SUPREP liquid into mixing container. Over the next hour, drink the whole solution plus at least two more. (3) • SUPREP Bowel Prep Kit (for pediatric patients 12 years of age and older): Two bottles each containing 4. A ginger hard candy or lemon slice may be helpful. On the DAY BEFORE your colonoscopy prepare your SuPrep solution in the morning: STEP 1: - Pour one of the 6 ounce bottles of Suprep liquid into the disposable mixing container. Pour one (1) 6 oz. The length of time it takes for Suprep to act and the duration of the action appear to be quite variable. On the evening before the colonoscopy, open 1 bottle of Suprep Bowel Prep Kit® and pour the contents into the mixing container provided. Like, would I be able to get in my car. do not open Suprep bottles yet. Mix the solution the evening before your colonoscopy and refrigerate before drinking. There are several colon-prep products that involve significantly less fluid that the standard prep. Drink the solution through a straw. Confusion, weakness, muscle cramps or twitching. It all comes down to science: Tomatoes contain an enzyme that reacts to cold temperatures, causing the cell membranes to break down and leaving you with a piece of fruit that's mushy and mealy. The straws get the Suprep past most of the. That is the goal. I still have brown liquid stool the morning of the test. -. I drank the whole bottle in about three big gulps. (3) • SUPREP Bowel Prep Kit (for pediatric patients 12 years of age and older): Two bottles each containing 4. (This applies to real maple syrup as well as commercial pancake syrup. You. Refrigerate the Suprep solution before drinking, it tastes better chilled. 1)] . Do not freeze insulin lispro or store it near the cooling element in a refrigerator. Moviprep ® Fill line Empty the contents of 1 pouch A and 1 pouch B into. do not open Suprep bottles yet. This is normal. Indeed, scientific evidence shows that refrigeration changes the structure of the starches in bread, causing them to crystallize, which makes the bread hard (aka stale). Drink all the liquid in the container. According to the U. No bad taste. 1)] . You take the first 6-ounce bottle of SUPREP the evening before your colonoscopy and the second 6-ounce bottle of SUPREP the morning of your colonoscopy. If you had a biopsy, it’s normal to have a small amount of bleeding from your rectum. So, I’ve had Crohn’s. Acetaminophen (Tylenol) can be continued or substituted as a pain-reliever for aspirin. Use the empty container to do this. You need to stay hydrated throughout the process. “We work closely with a patient. Also, drink plenty of clear liquids and avoid anything with red. 72 g. It is best eaten by the best before date printed on the packaging. Crystal Light Lemonade or Iced Tea can be substituted forCream-based sauces will need to be used up much more quickly. 2. If you feel nauseated, drink Suprep more slowly. There are some eye drops that don't need to be refrigerated, but they may have a shorter shelf life. 84 g, potassium chloride 2. (3) • SUPREP. 4. Others find it easier to drink itMethods: A dual-component suppression-and-replacement (SupRep) KCNQ1 gene therapy was created by cloning a KCNQ1 short hairpin RNA and a short hairpin RNA-immune KCNQ1 cDNA modified with synonymous variants in the short hairpin RNA target site, into a single construct. The cash price for this prep without insurance coverage is around $50. Use skin-soothing products such as baby rash ointment. Prepare the SUPREP solution: Empty ONE BOTTLE into the disposable container. You can place the preparation in the refrigerator, or set it on top of ice to cool it. I had my colonoscopy Aug. What the experts say: Although it contains vinegar, there's not enough in there to safely store this creamy, egg-rich condiment outside the fridge. You do not have to use water to mix the Suprep solution; You may use any approved clear liquids (White grape juice, Crystal Light & Sprite/7Up are good choices. Your doctor will tell you exactly when you should take your medication. You CANNOT refrigerate, which disappointed my mom because everything is easier to drink if it’s refrigerated or if it’s warm (room temp is worst, in her opinion). can i mix suprep with anything besides water. Someone on our team can call the pharmacy for you. Refrigerated cheese will last for several weeks to several months. 80, which means bacteria won't grow in it. Pour ONE 6-ounce bottle of SUPREP® liquid into the mixing container. Some of the preparations come with flavor packets which can be added to improve the taste. Official answer. Using a straw can help too. You need to stay hydrated throughout the process. 3. Patients generally do not like the sulfate taste, but nearly all seem to be able to complete the preparation. You will thank me. (3) • SUPREP Bowel Prep Kit (for pediatric patients 12 years of age and older): Two bottles each containing 4. When it comes to refrigerating Suprep, a brand of oral bowel cleansing medication, there are some important steps to ensure the safe storage of this medication. How long the colonoscopy prep process will take altogether varies, but passing clear or yellowish fluid that is free from fecal matter is an indication that your bowel prep is complete. 3. Below is a summary of known side effects for SUPREP Bowel Prep. glass every 15 minutes until the solution is gone. Suprep is a low-volume oral sulfate solution (OSS). Then pour one (1) six-ounce bottle of Suprep liquid into the mixing container and add water to the 16-ounce line on the container. SUPREP ® Bowel Prep Kit. Suprep Bowel Prep Kit has an average rating of 7. Along with its needed effects, magnesium sulfate/potassium sulfate/sodium sulfate may cause some unwanted effects. Animal reproduction studies have not been conducted with SUPREP Bowel Prep Kit. If you experience side effects when taking SUPREP Bowel Prep, be sure to tell your…1. • kidney problems. Sodium sulfate, potassium sulfate, and magnesium sulfate combination is used to cleanse the colon (bowel) before a colonoscopy. After they've been mixed, almost all PEG 3350/electrolytes bowel preps have to be refrigerated. 5 Gram-3. can i mix suprep with anything besides water can i mix suprep with anything besides water. This solution can be refrigerated. The Short Answer: Don't Refrigerate Tomatoes. The concentration of the. Administer tetracycline and fluoroquinolone antibiotics, iron, digoxin, chlorpromazine and penicillamine, at least 2 hours before and not less than 6 hours after administration of CLENPIQ to. 13 Gram-1.